Bulk Cyanotis Arachnoidea Extract Supplier — 20-Hydroxyecdysone 98% HPLC & 90/95% UV, B2B Wholesale

Written by Jonathan, Valeherb · Reviewed by Dr. Xiaoyan Qiu · Updated June 2026

Valeherb supplies Cyanotis arachnoidea extract in bulk wholesale, standardized to 20-hydroxyecdysone (20-HE / ecdysterone) — offered as 90% and 95% UV grades (total-ecdysteroid basis) and a 98% HPLC isolate (specific 20-HE) — with custom specifications for sports-nutrition, cosmetic-active, and pharmaceutical-research applications. Among phytoecdysteroid-bearing plants, Cyanotis arachnoidea root is the primary industrial raw material for high-purity 20-HE: spinach (Spinacia oleracea) carries only trace ecdysteroid levels, far too low for standardized supply at scale.^[1] A 2016 Scientific Reports study documented that European supplements marketed as spinach-derived were in fact manufactured from Cyanotis arachnoidea material — underlining its position as the practical commercial source.^[2]

Active Compounds and Research Profile

Cyanotis arachnoidea extract is defined by its phytoecdysteroid fraction, dominated by 20-hydroxyecdysone — also called ecdysterone or β-ecdysterone — as the primary marker compound. Chemically, 20-HE is a polyhydroxylated steroid (C₂₇H₄₄O₇, MW 480.6 g/mol, CAS 5289-74-7) that is structurally distinct from vertebrate steroid hormones. It does not bind androgen receptors; current research attributes its activity to non-androgenic pathways, with estrogen receptor beta (ERβ) signaling proposed as a primary mechanism in skeletal-muscle studies.^[3]

Minor ecdysteroid co-compounds — including 20-HE 2-acetate, 20-HE 3-acetate, ajugasterone C, and shidasterone — serve mainly as chromatographic fingerprint markers that confirm genuine Cyanotis-derived origin in routine HPLC quality control.^[2]

Available Grades and Specifications

High-purity ecdysteroid production requires substantial root biomass (on the order of several tonnes of dried Cyanotis arachnoidea root per commercial batch) and multi-step chromatographic purification. Valeherb supplies three commercial grades:

Research Evidence

A frequently cited human study is Isenmann et al. (2019) in Archives of Toxicology, a WADA-funded randomized controlled trial: across ten weeks of resistance training, participants taking ecdysterone showed greater gains in muscle mass and bench-press performance than placebo, with no androgenic changes to the steroid profile.^[4] Dinan et al. (2021) in Biomedicines provides a comprehensive mechanistic and clinical review, reporting in-vitro protein-synthesis stimulation of up to ~20% in human primary myotubes at 1 µM 20-HE (comparable to IGF-1 in the same assay), and summarizing purification processes relevant to pharmaceutical-grade production — useful context for B2B buyers assessing supplier qualification.^[3] Investigational pharmaceutical programs (e.g., the BIO101 development program) are studying 20-HE in further research settings.^[3]

These findings describe published research on the 20-hydroxyecdysone compound and are provided for informational purposes only; they are not claims for any finished product.

Formulation Applications

• Sports-nutrition capsules and powders: 90% or 95% UV grade is the standard commercial format, typically 200–500 mg per serving. The non-androgenic profile supports clean-label positioning. Bioavailability enhancers (piperine, phospholipid complexes) are commonly co-formulated to address the low oral bioavailability of 20-HE
• Cosmetic actives: 95% UV or 98% HPLC grade at low use levels (typically 0.01–0.1%) in leave-on formats. Higher purity improves aqueous-system integration; the compound has been studied in skin-cell research, with finished-product claims kept within cosmetic scope
• Pharmaceutical & research reference: 98% HPLC isolate with full chain-of-custody documentation for research use and as an analytical reference standard for QC laboratories verifying ecdysteroid content in finished products
• Analytical reference material: Certificate-grade 20-HE for laboratories — a growing requirement as anti-doping and food-safety bodies increase scrutiny of this ingredient category

Sourcing Criteria for B2B Buyers

Regulatory Guidance

• United States: Dietary-supplement ingredient under DSHEA; not a controlled substance. Structure/function claims are permitted only with marketer-held substantiation and the required FDA disclaimer; published research (e.g., the Isenmann RCT) is part of the scientific literature but does not by itself substantiate a specific finished-product claim. FDA-registered facility (21 CFR Part 111 cGMP) required
• European Union: Marketed as a food-supplement ingredient across EU member states. Monitor EFSA for any future maximum-level or novel-food guidance on ecdysteroid-containing products
• China: Cultivated primarily in Yunnan and Guangxi; governed by NMPA regulations for domestic applications. Valeherb’s bulk supply includes export documentation for domestic and international shipments

References