Bulk Centella Asiatica (Gotu Kola) Extract Supplier — Asiaticoside, Madecassoside, Total Glycosides, CICA & TECA Grades, B2B Wholesale
Valeherb supplies Centella asiatica extract bulk wholesale — also known as gotu kola extract — from Centella asiatica (L.) Urban aerial parts, across single-compound, total-glycoside, and combined glycoside-and-acid grades. Every grade ships with a per-batch COA reporting individual HPLC-quantified compound content, not only a combined total, since the ratio between the glycoside fraction and the acid (aglycone) fraction is what actually determines formulation behavior.
On this page: available grades, glycosides vs acids, active compound profile, research background, formulation applications, sourcing criteria, and regulatory guidance.
Available Grades
| Product Line | Grades | Compound Basis |
|---|---|---|
| Asiaticoside | 80% / 90% / 98% | Single-compound glycoside, HPLC |
| Madecassoside (Hydroxyasiaticoside) | 90% / 95% | Single-compound glycoside, HPLC |
| Total Centella Glycosides | 10% / 20% / 40% / 70% / 80% | Combined asiaticoside + madecassoside + asiaticoside B, HPLC |
| Total Triterpenes | 40% / 70% | Glycoside-dominant; acid fraction typically negligible (<1%) at these grades |
| CICA | 80% | Combined glycosides + acids (asiatic acid, madecassic acid) |
| TECA | 95% | Combined glycosides + acids, acid-fraction typically dominant |
All grades are standardized by HPLC against certified reference standards. Custom ratios and packaging available on request. INCI: Centella Asiatica Extract, Asiaticoside, and/or Madecassoside as applicable to the standardized grade.
Glycosides vs Acids: The Distinction That Actually Matters
Centella asiatica‘s triterpenoid fraction exists in two related but functionally distinct forms. Asiaticoside, madecassoside, and asiaticoside B are glycosides — sugar-bound, water/hydro-alcohol soluble, and the basis of the single-compound and Total Glycosides product lines. Asiatic acid and madecassic acid are the corresponding acids (aglycones) — sugar-free, more lipophilic, and present at guaranteed levels only in the CICA and TECA lines. These are not interchangeable, and the internal ratio between compounds can vary batch to batch even within the same nominal grade.
Active Compound Profile
| Compound | Form | Research Characterization |
|---|---|---|
| Asiaticoside | Glycoside | Studied for fibroblast proliferation and Type I collagen-pathway activity via TGF-β signaling[2] |
| Madecassoside | Glycoside (hydroxyasiaticoside) | Studied for inflammatory-pathway activity (COX / PGE2)[2] |
| Asiaticoside B | Glycoside | Co-occurring glycoside; contributes to total glycoside content in the Total Glycosides, Total Triterpenes, and CICA/TECA lines |
| Asiatic acid / Madecassic acid | Acids (aglycones) | More lipophilic than the glycosides; studied for collagen and antioxidant, and inflammatory-pathway endpoints respectively[2] |
Centella asiatica (gotu kola) is defined by its pentacyclic triterpenoid fraction, where the individual compound profile — not just total content — is the critical specification.[1] In published research, topical Centella triterpene preparations have been studied for skin-barrier and re-epithelialization endpoints, with a 2022 systematic review of four clinical trials reporting measurable effects on skin-recovery endpoints with triterpene-standardized preparations.[3] These describe research on the compound class and are provided for informational purposes only; they are not claims for any finished product.
Formulation Applications
- Aqueous soothing serums and toners: Single-compound or Total Glycosides grades, fully water/hydro-alcohol soluble at 0.5–2.5% in the finished formula. Triterpenes are most stable around pH 4.5–6.5
- Anti-aging / firmness-appearance serums: Higher-purity asiaticoside or CICA/TECA grades. Formulates well with niacinamide, peptides, and hyaluronic acid
- Soothing and barrier-support moisturizers: Madecassoside-forward grades are the typical choice for calming “cica” formats. Compatible with ceramides, panthenol, and allantoin
- Precision actives requiring guaranteed acid content: CICA 80% or TECA 95% — request the individual compound breakdown on the batch COA. For skin/INCI-specific formulation guidance, see Gotu Kola Extract for Skin: INCI, Solubility, and Formulation Guide
Sourcing Criteria for B2B Buyers
| Criterion | What to Require |
|---|---|
| Individual Compound Breakdown | HPLC-verified asiaticoside, madecassoside, asiaticoside B, asiatic acid, and madecassic acid reported separately — not combined as a single total, especially for CICA and TECA grades |
| Glycoside vs Acid Requirement | Confirm whether your formulation needs guaranteed acid content (CICA / TECA) or a near-pure glycoside profile (Total Glycosides / Total Triterpenes) |
| Solubility | Glycoside grades are water/hydro-alcohol soluble; the acid fraction in CICA/TECA is more alcohol-soluble. Confirm which fraction dominates before finalizing your formulation phase |
| Third-Party COA & Certifications | Individual compound % (HPLC), heavy metals, solvent residues, microbial limits, moisture per batch. Non-GMO; COSMOS/ECOCERT; Halal/Kosher; FDA-registered facility for US supply |
Regulatory Guidance
- EU (Cosmetics): INCI names Centella Asiatica Extract, Asiaticoside, and Madecassoside as applicable; regulated under EU Cosmetics Regulation (EC) No 1223/2009. A safety assessment (CPSR) is required for all marketed cosmetic products
- United States: Cosmetic ingredient with no FDA-specific restriction in cosmetic use. Wound-healing or therapeutic claims move a finished product into OTC-drug territory. Oral supplement use is governed by DSHEA (21 CFR Part 111)
- China: Listed in the NMPA Cosmetic Ingredient Inventory (IECIC). NMPA-compliant documentation available from Valeherb for China cosmetic registration support
References
[1] Hein ZM, Gopalakrishna PK, Kanuri AK, et al. (2025). Centella asiatica: Advances in Extraction Technologies, Phytochemistry, and Therapeutic Applications. Life, 15(7), 1081. doi:10.3390/life15071081
[2] Witkowska K, Paczkowska-Walendowska M, Garbiec E, Cielecka-Piontek J. (2024). Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy. Pharmaceutics, 16(10), 1252. doi:10.3390/pharmaceutics16101252
[3] Arribas-López E, Zand N, Ojo O, Snowden MJ, Kochhar T. (2022). A Systematic Review of the Effect of Centella asiatica on Wound Healing. International Journal of Environmental Research and Public Health, 19(6), 3266. doi:10.3390/ijerph19063266
[4] Johnson W, Bergfeld WF, Belsito DV, et al. (2023). Safety Assessment of Centella asiatica-Derived Ingredients as Used in Cosmetics. International Journal of Toxicology, 42(1_suppl), 5S–22S. doi:10.1177/10915818231158272
